New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

Dysregulated NLRP3 inflammasome activity results in uncontrolled inflammation, which underlies many chronic diseases. Although mitochondrial damage is needed for the assembly and activation of the NLRP3 inflammasome, it is unclear how macrophages are able to respond to structurally diverse inflammas...

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Publicado en:Nature
Main Authors: Zhong, Zhenyu, Liang, Shuang, Sanchez-Lopez, Elsa, He, Feng, Shalapour, Shabnam, Lin, Xue-jia, Wong, Jerry, Ding, Siyuan, Seki, Ekihiro, Schnabl, Bernd, Hevener, Andrea L., Greenberg, Harry B., Kisseleva, Tatiana, Karin, Michael
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329306/
https://ncbi.nlm.nih.gov/pubmed/30046112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0372-z
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