MLL-AF9– and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C

Self-renewal is a hallmark of both hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs); therefore, the identification of mechanisms that are required for LSC, but not HSC, function could provide therapeutic opportunities that are more effective and less toxic than current treatments. Here...

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Publicado en:J Clin Invest
Main Authors: Zhu, Nan, Chen, Mo, Eng, Rowena, DeJong, Joshua, Sinha, Amit U., Rahnamay, Noushin F., Koche, Richard, Al-Shahrour, Fatima, Minehart, Janna C., Chen, Chun-Wei, Deshpande, Aniruddha J., Xu, Haiming, Chu, S. Haihua, Ebert, Benjamin L., Roeder, Robert G., Armstrong, Scott A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767347/
https://ncbi.nlm.nih.gov/pubmed/26878175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI82978
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