Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis

MLL1 fusion proteins activate HoxA9 gene expression and cause aggressive leukemias that respond poorly to treatment, but how they recognize and stably bind to HoxA9 is not clearly understood. In a systematic analysis of MLL1 domain recruitment activity, we identified an essential MLL1 recruitment do...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Milne, Thomas A., Kim, Jaehoon, Wang, Gang G., Stadler, Sonja C., Basrur, Venkatesha, Whitcomb, Sarah J., Wang, Zhanxin, Ruthenburg, Alexander J., Elenitoba-Johnson, Kojo S. J., Roeder, Robert G., Allis, C. David
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902588/
https://ncbi.nlm.nih.gov/pubmed/20541448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.05.011
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados