Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis

MLL1 fusion proteins activate HoxA9 gene expression and cause aggressive leukemias that respond poorly to treatment, but how they recognize and stably bind to HoxA9 is not clearly understood. In a systematic analysis of MLL1 domain recruitment activity, we identified an essential MLL1 recruitment do...

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Hauptverfasser: Milne, Thomas A., Kim, Jaehoon, Wang, Gang G., Stadler, Sonja C., Basrur, Venkatesha, Whitcomb, Sarah J., Wang, Zhanxin, Ruthenburg, Alexander J., Elenitoba-Johnson, Kojo S. J., Roeder, Robert G., Allis, C. David
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902588/
https://ncbi.nlm.nih.gov/pubmed/20541448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.05.011
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