The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis

MLL is involved in chromosomal rearrangements that generate fusion proteins with deregulated transcriptional activity. The mechanisms of MLL fusion protein-mediated transcriptional activation are poorly understood. Here we show MLL interacts directly with the Polymerase Associated Factor complex (PA...

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Autores principales: Muntean, Andrew G., Tan, Jiaying, Sitwala, Kajal, Huang, Yongsheng, Bronstein, Joel, Connelly, James A., Basrur, Venkatesha, Elenitoba-Johnson, Kojo S. J., Hess, Jay L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888888/
https://ncbi.nlm.nih.gov/pubmed/20541477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.04.012
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