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Full Length Single Chain Fc Protein (FLSC IgG1) as a Potent Antiviral Therapy Candidate: Implications for In Vivo Studies
We have previously shown that FLSC, a chimeric protein containing HIV-1(BAL) gp120 and the D1 and D2 domains of human CD4, blocks the binding and entry of HIV-1 into target cells by occluding CCR5, the major HIV-1 coreceptor. In an effort to improve the antiviral potential of FLSC, we fused it with...
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| 發表在: | AIDS Res Hum Retroviruses |
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| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Mary Ann Liebert, Inc.
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4761833/ https://ncbi.nlm.nih.gov/pubmed/26059995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2015.0020 |
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