Antigen-Induced Allosteric Changes in a Human IgG1 Fc Increase Low-Affinity Fcγ Receptor Binding

Antibody structure couples adaptive and innate immunity via Fab (antigen binding) and Fc (effector) domains that are connected by unique hinge regions. Because antibodies harbor two or more Fab domains, they are capable of cross-linking multi-determinant antigens, which is required for Fc-dependent...

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Détails bibliographiques
Publié dans:Structure
Auteurs principaux: Orlandi, Chiara, Deredge, Daniel, Ray, Krishanu, Gohain, Neelakshi, Tolbert, William, DeVico, Anthony L., Wintrode, Patrick, Pazgier, Marzena, Lewis, George K.
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7288244/
https://ncbi.nlm.nih.gov/pubmed/32209433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2020.03.001
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