Antigen-Induced Allosteric Changes in a Human IgG1 Fc Increase Low-Affinity Fcγ Receptor Binding

Antibody structure couples adaptive and innate immunity via Fab (antigen binding) and Fc (effector) domains that are connected by unique hinge regions. Because antibodies harbor two or more Fab domains, they are capable of cross-linking multi-determinant antigens, which is required for Fc-dependent...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Structure
Hlavní autoři: Orlandi, Chiara, Deredge, Daniel, Ray, Krishanu, Gohain, Neelakshi, Tolbert, William, DeVico, Anthony L., Wintrode, Patrick, Pazgier, Marzena, Lewis, George K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7288244/
https://ncbi.nlm.nih.gov/pubmed/32209433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2020.03.001
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky