Defining rules governing recognition and Fc-mediated effector functions to the HIV-1 co-receptor binding site

BACKGROUND: The binding of HIV-1 Envelope glycoproteins (Env) to host receptor CD4 exposes vulnerable conserved epitopes within the co-receptor binding site (CoRBS) which are required for the engagement of either CCR5 or CXCR4 co-receptor to allow HIV-1 entry. Antibodies against this region have bee...

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Publicat a:BMC Biol
Autors principals: Tolbert, William D., Sherburn, Rebekah, Gohain, Neelakshi, Ding, Shilei, Flinko, Robin, Orlandi, Chiara, Ray, Krishanu, Finzi, Andrés, Lewis, George K., Pazgier, Marzena
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7374964/
https://ncbi.nlm.nih.gov/pubmed/32693837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-020-00819-y
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