Induction of Fc-Mediated Effector Functions Against a Stabilized Inner Domain of HIV-1 gp120 Designed to Selectively Harbor the A32 Epitope Region

Recent clinical trials and studies using nonhuman primates (NHPs) suggest that antibody-mediated protection against HIV-1 will require α-HIV envelope humoral immunity beyond direct neutralization to include Fc-receptor (FcR) mediated effector functions such as antibody-dependent cellular cytotoxicit...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Visciano, Maria L., Gohain, Neelakshi, Sherburn, Rebekah, Orlandi, Chiara, Flinko, Robin, Dashti, Amir, Lewis, George K., Tolbert, William D., Pazgier, Marzena
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6455405/
https://ncbi.nlm.nih.gov/pubmed/31001276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00677
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