Paring Down HIV Env: Design and Crystal Structure of a Stabilized Inner Domain of HIV-1 gp120 Displaying a Major ADCC Target of the A32 Region

Evidence supports a role of antibody-dependent cellular cytotoxicity (ADCC) toward transitional epitopes in the first and second constant (C1-C2) regions of gp120 (A32-like epitopes) in preventing HIV-1 infection and in vaccine-induced protection. Here, we describe the first successful attempt at is...

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Detalhes bibliográficos
Publicado no:Structure
Main Authors: Tolbert, William D., Gohain, Neelakshi, Veillette, Maxime, Chapleau, Jean-Philippe, Orlandi, Chiara, Visciano, Maria L., Ebadi, Maryam, DeVico, Anthony L., Fouts, Timothy R., Finzi, Andrés, Lewis, George K., Pazgier, Marzena
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856543/
https://ncbi.nlm.nih.gov/pubmed/27041594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.03.005
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