Antigen-Induced Allosteric Changes in a Human IgG1 Fc Increase Low-Affinity Fcγ Receptor Binding

Antibody structure couples adaptive and innate immunity via Fab (antigen binding) and Fc (effector) domains that are connected by unique hinge regions. Because antibodies harbor two or more Fab domains, they are capable of cross-linking multi-determinant antigens, which is required for Fc-dependent...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Structure
Asıl Yazarlar: Orlandi, Chiara, Deredge, Daniel, Ray, Krishanu, Gohain, Neelakshi, Tolbert, William, DeVico, Anthony L., Wintrode, Patrick, Pazgier, Marzena, Lewis, George K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7288244/
https://ncbi.nlm.nih.gov/pubmed/32209433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2020.03.001
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