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Antigen-Induced Allosteric Changes in a Human IgG1 Fc Increase Low-Affinity Fcγ Receptor Binding
Antibody structure couples adaptive and innate immunity via Fab (antigen binding) and Fc (effector) domains that are connected by unique hinge regions. Because antibodies harbor two or more Fab domains, they are capable of cross-linking multi-determinant antigens, which is required for Fc-dependent...
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| Publicat a: | Structure |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7288244/ https://ncbi.nlm.nih.gov/pubmed/32209433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2020.03.001 |
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