Full Length Single Chain Fc Protein (FLSC IgG1) as a Potent Antiviral Therapy Candidate: Implications for In Vivo Studies

We have previously shown that FLSC, a chimeric protein containing HIV-1(BAL) gp120 and the D1 and D2 domains of human CD4, blocks the binding and entry of HIV-1 into target cells by occluding CCR5, the major HIV-1 coreceptor. In an effort to improve the antiviral potential of FLSC, we fused it with...

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Podrobná bibliografie
Vydáno v:AIDS Res Hum Retroviruses
Hlavní autoři: Latinovic, Olga S., Medina-Moreno, Sandra, Schneider, Kate, Gohain, Neelakshi, Zapata, Juan, Pazgier, Marzena, Reitz, Marvin, Bryant, Joseph, Redfield, Robert R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2016
Témata:
Preclinical Studies/Drug Development
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761833/
https://ncbi.nlm.nih.gov/pubmed/26059995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2015.0020
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