Gain-of-Function Mutation W493R in the Epithelial Sodium Channel Allosterically Reconfigures Intersubunit Coupling

Sodium absorption in epithelial cells is rate-limited by the epithelial sodium channel (ENaC) activity in lung, kidney, and the distal colon. Pathophysiological conditions, such as cystic fibrosis and Liddle syndrome, result from water-electrolyte imbalance partly due to malfunction of ENaC regulati...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Shobair, Mahmoud, Dagliyan, Onur, Kota, Pradeep, Dang, Yan L., He, Hong, Stutts, M. Jackson, Dokholyan, Nikolay V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Molecular Biophysics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759151/
https://ncbi.nlm.nih.gov/pubmed/26668308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.678052
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