Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase

N-Myristoyltransferase (NMT) is a potential drug target in Leishmania parasites. Scaffold-hopping from published inhibitors yielded the serendipitous discovery of a chemotype selective for Leishmania donovani NMT; development led to high affinity inhibitors with excellent ligand efficiency. The bind...

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Udgivet i:Medchemcomm
Main Authors: Rackham, Mark D., Yu, Zhiyong, Brannigan, James A., Heal, William P., Paape, Daniel, Barker, K. Victoria, Wilkinson, Anthony J., Smith, Deborah F., Leatherbarrow, Robin J., Tate, Edward W.
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2015
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4757855/
https://ncbi.nlm.nih.gov/pubmed/26962429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5md00241a
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