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Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase
N-Myristoyltransferase (NMT) is a potential drug target in Leishmania parasites. Scaffold-hopping from published inhibitors yielded the serendipitous discovery of a chemotype selective for Leishmania donovani NMT; development led to high affinity inhibitors with excellent ligand efficiency. The bind...
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| Udgivet i: | Medchemcomm |
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| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Royal Society of Chemistry
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4757855/ https://ncbi.nlm.nih.gov/pubmed/26962429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5md00241a |
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