Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3' regulatory region

The IgH 3' regulatory region (3'RR) controls class switch recombination (CSR) and somatic hypermutation (SHM) in B cells. The mouse 3'RR contains four enhancer elements with hs1,2 flanked by inverted repeated sequences and the centre of a 25-kb palindrome bounded by two hs3 enhancer i...

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Vydáno v:Nat Commun
Hlavní autoři: Saintamand, Alexis, Vincent-Fabert, Christelle, Garot, Armand, Rouaud, Pauline, Oruc, Zeliha, Magnone, Virginie, Cogné, Michel, Denizot, Yves
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4757795/
https://ncbi.nlm.nih.gov/pubmed/26883548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10730
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