A Phase I Study of DMS612, a Novel Bi-functional Alkylating Agent

PURPOSE: DMS612 is a dimethane sulfonate analog with bifunctional alkylating activity and preferential cytotoxicity to human renal cell carcinoma (RCC) in the NCI-60 cell panel. This first-in-human phase I study aimed to determine dose-limiting toxicity (DLT), maximum tolerated dose (MTD), pharmacok...

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Publicado en:Clin Cancer Res
Main Authors: Appleman, Leonard J., Balasubramaniam, Sanjeeve, Parise, Robert A, Bryla, Christine, Redon, Christophe E., Nakamura, Asako J., Bonner, William M., Wright, John J, Piekarz, Richard, Kohler, David R, Jiang, Yixing, Belani, Chandra P., Eiseman, Julie, Chu, Edward, Beumer, Jan H., Bates, Susan E.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755291/
https://ncbi.nlm.nih.gov/pubmed/25467180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-1333
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