Combination Therapy With Reovirus and Anti-PD-1 Blockade Controls Tumor Growth Through Innate and Adaptive Immune Responses

Oncolytic reovirus can be delivered both systemically and intratumorally, in both preclinical models and in early phase clinical trials. Reovirus has direct oncolytic activity against a variety of tumor types and antitumor activity is directly associated with immune activation by virus replication i...

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發表在:Mol Ther
Main Authors: Rajani, Karishma, Parrish, Christopher, Kottke, Timothy, Thompson, Jill, Zaidi, Shane, Ilett, Liz, Shim, Kevin G, Diaz, Rosa-Maria, Pandha, Hardev, Harrington, Kevin, Coffey, Matt, Melcher, Alan, Vile, Richard
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2016
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754544/
https://ncbi.nlm.nih.gov/pubmed/26310630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.156
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