Combination Therapy With Reovirus and Anti-PD-1 Blockade Controls Tumor Growth Through Innate and Adaptive Immune Responses

Oncolytic reovirus can be delivered both systemically and intratumorally, in both preclinical models and in early phase clinical trials. Reovirus has direct oncolytic activity against a variety of tumor types and antitumor activity is directly associated with immune activation by virus replication i...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Rajani, Karishma, Parrish, Christopher, Kottke, Timothy, Thompson, Jill, Zaidi, Shane, Ilett, Liz, Shim, Kevin G, Diaz, Rosa-Maria, Pandha, Hardev, Harrington, Kevin, Coffey, Matt, Melcher, Alan, Vile, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754544/
https://ncbi.nlm.nih.gov/pubmed/26310630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.156
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