Combination Therapy With Reovirus and Anti-PD-1 Blockade Controls Tumor Growth Through Innate and Adaptive Immune Responses

Oncolytic reovirus can be delivered both systemically and intratumorally, in both preclinical models and in early phase clinical trials. Reovirus has direct oncolytic activity against a variety of tumor types and antitumor activity is directly associated with immune activation by virus replication i...

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Dettagli Bibliografici
Pubblicato in:Mol Ther
Autori principali: Rajani, Karishma, Parrish, Christopher, Kottke, Timothy, Thompson, Jill, Zaidi, Shane, Ilett, Liz, Shim, Kevin G, Diaz, Rosa-Maria, Pandha, Hardev, Harrington, Kevin, Coffey, Matt, Melcher, Alan, Vile, Richard
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754544/
https://ncbi.nlm.nih.gov/pubmed/26310630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.156
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