Pro-inflammatory cytokine/chemokine production by reovirus treated melanoma cells is PKR/NF-κB mediated and supports innate and adaptive anti-tumour immune priming

BACKGROUND: As well as inducing direct oncolysis, reovirus treatment of melanoma is associated with activation of innate and adaptive anti-tumour immune responses. RESULTS: Here we characterise the effects of conditioned media from reovirus-infected, dying human melanoma cells (reoTCM), in the absen...

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Bibliografiska uppgifter
Huvudupphovsmän: Steele, Lynette, Errington, Fiona, Prestwich, Robin, Ilett, Elizabeth, Harrington, Kevin, Pandha, Hardev, Coffey, Matt, Selby, Peter, Vile, Richard, Melcher, Alan
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2011
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3052210/
https://ncbi.nlm.nih.gov/pubmed/21338484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-20
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