Prime-boost using Separate Oncolytic Viruses in Combination with Checkpoint Blockade Improves Anti-tumor Therapy

The anti-tumor effects associated with oncolytic virus therapy are mediated significantly through immune-mediated mechanisms which depends both on the type of virus and the route of delivery. Here, we show that intra-tumoral (i.t.) oncolysis by Reovirus induced the priming of a CD8+, Th1-type anti-t...

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Gepubliceerd in:Gene Ther
Hoofdauteurs: Ilett, Elizabeth, Kottke, Timothy, Thompson, Jill, Rajani, Karishma, Zaidi, Shane, Evgin, Laura, Coffey, Matt, Ralph, Christy, Diaz, Rosa, Pandha, Hardev, Harrington, Kevin, Selby, Peter, Bram, Richard, Melcher, Alan, Vile, Richard
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5387692/
https://ncbi.nlm.nih.gov/pubmed/27779616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2016.70
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