Cytokine Conditioning Enhances Systemic Delivery and Therapy of an Oncolytic Virus

Optimum clinical protocols require systemic delivery of oncolytic viruses in the presence of an intact immune system. We show that preconditioning with immune modulators, or loading virus onto carrier cells ex vivo, enhances virus-mediated antitumor activity. Our early trials of systemic reovirus de...

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Библиографические подробности
Опубликовано в: :Mol Ther
Главные авторы: Ilett, Elizabeth, Kottke, Timothy, Donnelly, Oliver, Thompson, Jill, Willmon, Candice, Diaz, Rosa, Zaidi, Shane, Coffey, Matt, Selby, Peter, Harrington, Kevin, Pandha, Hardev, Melcher, Alan, Vile, Richard
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2014
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428400/
https://ncbi.nlm.nih.gov/pubmed/24957982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.118
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