Cytokine Conditioning Enhances Systemic Delivery and Therapy of an Oncolytic Virus

Optimum clinical protocols require systemic delivery of oncolytic viruses in the presence of an intact immune system. We show that preconditioning with immune modulators, or loading virus onto carrier cells ex vivo, enhances virus-mediated antitumor activity. Our early trials of systemic reovirus de...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Ther
Prif Awduron: Ilett, Elizabeth, Kottke, Timothy, Donnelly, Oliver, Thompson, Jill, Willmon, Candice, Diaz, Rosa, Zaidi, Shane, Coffey, Matt, Selby, Peter, Harrington, Kevin, Pandha, Hardev, Melcher, Alan, Vile, Richard
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2014
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428400/
https://ncbi.nlm.nih.gov/pubmed/24957982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.118
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