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Cytokine Conditioning Enhances Systemic Delivery and Therapy of an Oncolytic Virus
Optimum clinical protocols require systemic delivery of oncolytic viruses in the presence of an intact immune system. We show that preconditioning with immune modulators, or loading virus onto carrier cells ex vivo, enhances virus-mediated antitumor activity. Our early trials of systemic reovirus de...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Mol Ther |
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| Prif Awduron: | , , , , , , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Nature Publishing Group
2014
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4428400/ https://ncbi.nlm.nih.gov/pubmed/24957982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.118 |
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