Cytokine Conditioning Enhances Systemic Delivery and Therapy of an Oncolytic Virus

Optimum clinical protocols require systemic delivery of oncolytic viruses in the presence of an intact immune system. We show that preconditioning with immune modulators, or loading virus onto carrier cells ex vivo, enhances virus-mediated antitumor activity. Our early trials of systemic reovirus de...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Ilett, Elizabeth, Kottke, Timothy, Donnelly, Oliver, Thompson, Jill, Willmon, Candice, Diaz, Rosa, Zaidi, Shane, Coffey, Matt, Selby, Peter, Harrington, Kevin, Pandha, Hardev, Melcher, Alan, Vile, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428400/
https://ncbi.nlm.nih.gov/pubmed/24957982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.118
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