Improved Systemic Delivery of Oncolytic Reovirus to Established Tumors Using Preconditioning with Cyclophosphamide-Mediated Treg Modulation and Interleukin-2

PURPOSE: The goals of this study were (a) to investigate whether preconditioning of immuno-competent mice with PC-61-mediated regulatory T-cell (Treg) depletion and interleukin-2 (IL-2) would enhance systemic delivery of reovirus into subcutaneous tumors and (b) to test whether cyclophosphamide (CPA...

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Bibliografiske detaljer
Main Authors: Kottke, Timothy, Thompson, Jill, Diaz, Rosa Maria, Pulido, Jose, Willmon, Candice, Coffey, Matt, Selby, Peter, Melcher, Alan, Harrington, Kevin, Vile, Richard G.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046733/
https://ncbi.nlm.nih.gov/pubmed/19147761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-1688
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