Potent Multi-target FAAH-COX Inhibitors: Design and Structure-Activity Relationship Studies

Non-steroidal anti-inflammatory drugs (NSAIDs) exert their pharmacological effects by inhibiting cyclooxygenase (COX)-1 and COX-2. Though widely prescribed for pain and inflammation, these agents have limited utility in chronic diseases due to serious mechanism-based adverse events such as gastroint...

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Veröffentlicht in:Eur J Med Chem
Hauptverfasser: Migliore, Marco, Habrant, Damien, Sasso, Oscar, Albani, Clara, Bertozzi, Sine Mandrup, Armirotti, Andrea, Piomelli, Daniele, Scarpelli, Rita
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4752335/
https://ncbi.nlm.nih.gov/pubmed/26774927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2015.12.036
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