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BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice

Precise regulation of transcription is crucial for the cellular mechanisms underlying memory formation. However, the link between neuronal stimulation and the proteins that directly interact with histone modifications to activate transcription in neurons remains unclear. Brd4 is a member of the BET...

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Publicat a:Nat Neurosci
Autors principals: Korb, Erica, Herre, Margo, Zucker-Scharff, Ilana, Darnell, Robert B., Allis, C. David
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4752120/
https://ncbi.nlm.nih.gov/pubmed/26301327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4095
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