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The BET/BRD inhibitor JQ1 improves brain plasticity in WT and APP mice
Histone acetylation is essential for memory formation and its deregulation contributes to the pathogenesis of Alzheimer’s disease. Thus, targeting histone acetylation is discussed as a novel approach to treat dementia. The histone acetylation landscape is shaped by chromatin writer and eraser protei...
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| 出版年: | Transl Psychiatry |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5639246/ https://ncbi.nlm.nih.gov/pubmed/28949335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2017.202 |
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