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The BET/BRD inhibitor JQ1 improves brain plasticity in WT and APP mice

Histone acetylation is essential for memory formation and its deregulation contributes to the pathogenesis of Alzheimer’s disease. Thus, targeting histone acetylation is discussed as a novel approach to treat dementia. The histone acetylation landscape is shaped by chromatin writer and eraser protei...

詳細記述

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書誌詳細
出版年:Transl Psychiatry
主要な著者: Benito, E, Ramachandran, B, Schroeder, H, Schmidt, G, Urbanke, H, Burkhardt, S, Capece, V, Dean, C, Fischer, A
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5639246/
https://ncbi.nlm.nih.gov/pubmed/28949335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2017.202
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