The BET/BRD inhibitor JQ1 improves brain plasticity in WT and APP mice

Histone acetylation is essential for memory formation and its deregulation contributes to the pathogenesis of Alzheimer’s disease. Thus, targeting histone acetylation is discussed as a novel approach to treat dementia. The histone acetylation landscape is shaped by chromatin writer and eraser protei...

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Bibliografiske detaljer
Udgivet i:Transl Psychiatry
Main Authors: Benito, E, Ramachandran, B, Schroeder, H, Schmidt, G, Urbanke, H, Burkhardt, S, Capece, V, Dean, C, Fischer, A
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5639246/
https://ncbi.nlm.nih.gov/pubmed/28949335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2017.202
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