The BET/BRD inhibitor JQ1 improves brain plasticity in WT and APP mice

Histone acetylation is essential for memory formation and its deregulation contributes to the pathogenesis of Alzheimer’s disease. Thus, targeting histone acetylation is discussed as a novel approach to treat dementia. The histone acetylation landscape is shaped by chromatin writer and eraser protei...

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Publicat a:Transl Psychiatry
Autors principals: Benito, E, Ramachandran, B, Schroeder, H, Schmidt, G, Urbanke, H, Burkhardt, S, Capece, V, Dean, C, Fischer, A
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5639246/
https://ncbi.nlm.nih.gov/pubmed/28949335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2017.202
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