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The Structural Basis of Asymmetry in DNA Binding and Cleavage as Exhibited by the I-SmaMI LAGLIDADG Meganuclease

LAGLIDADG homing endonucleases (“meganucleases”) are highly specific DNA cleaving enzymes that are used for genome engineering. Like other enzymes that act on DNA targets, meganucleases often display binding affinities and cleavage activities that are dominated by one protein domain. To decipher the...

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Bibliografiske detaljer
Udgivet i:J Mol Biol
Main Authors: Shen, Betty W., Lambert, Abigail, Walker, Bradley C., Stoddard, Barry L., Kaiser, Brett K.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749321/
https://ncbi.nlm.nih.gov/pubmed/26705195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.12.005
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