Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space

LAGLIDADG homing endonucleases (LHEs) are a family of highly specific DNA endonucleases capable of recognizing target sequences ∼20 bp in length, thus drawing intense interest for their potential academic, biotechnological and clinical applications. Methods for rational design of LHEs to cleave desi...

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Detalhes bibliográficos
Main Authors: Jacoby, Kyle, Metzger, Michael, Shen, Betty W., Certo, Michael T., Jarjour, Jordan, Stoddard, Barry L., Scharenberg, Andrew M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367166/
https://ncbi.nlm.nih.gov/pubmed/22334611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1303
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