Force sensing by the vascular protein von Willebrand factor is tuned by a strong intermonomer interaction

The large plasma glycoprotein von Willebrand factor (VWF) senses hydrodynamic forces in the bloodstream and responds to elevated forces with abrupt elongation, thereby increasing its adhesiveness to platelets and collagen. Remarkably, forces on VWF are elevated at sites of vascular injury, where VWF...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Müller, Jochen P., Mielke, Salomé, Löf, Achim, Obser, Tobias, Beer, Christof, Bruetzel, Linda K., Pippig, Diana A., Vanderlinden, Willem, Lipfert, Jan, Schneppenheim, Reinhard, Benoit, Martin
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747740/
https://ncbi.nlm.nih.gov/pubmed/26787887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516214113
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