Advancing multimer analysis of von Willebrand factor by single-molecule AFM imaging

The formation of hemostatic plugs at sites of vascular injury crucially involves the multimeric glycoprotein von Willebrand factor (VWF). VWF multimers are linear chains of N-terminally linked dimers. The latter are formed from monomers via formation of the C-terminal disulfide bonds Cys2771-Cys2773...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Löf, Achim, König, Gesa, Schneppenheim, Sonja, Schneppenheim, Reinhard, Benoit, Martin, Budde, Ulrich, Müller, Jochen P., Brehm, Maria A.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333368/
https://ncbi.nlm.nih.gov/pubmed/30645640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0210963
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