Force sensing by the vascular protein von Willebrand factor is tuned by a strong intermonomer interaction

The large plasma glycoprotein von Willebrand factor (VWF) senses hydrodynamic forces in the bloodstream and responds to elevated forces with abrupt elongation, thereby increasing its adhesiveness to platelets and collagen. Remarkably, forces on VWF are elevated at sites of vascular injury, where VWF...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Müller, Jochen P., Mielke, Salomé, Löf, Achim, Obser, Tobias, Beer, Christof, Bruetzel, Linda K., Pippig, Diana A., Vanderlinden, Willem, Lipfert, Jan, Schneppenheim, Reinhard, Benoit, Martin
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747740/
https://ncbi.nlm.nih.gov/pubmed/26787887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516214113
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