Force sensing by the vascular protein von Willebrand factor is tuned by a strong intermonomer interaction

The large plasma glycoprotein von Willebrand factor (VWF) senses hydrodynamic forces in the bloodstream and responds to elevated forces with abrupt elongation, thereby increasing its adhesiveness to platelets and collagen. Remarkably, forces on VWF are elevated at sites of vascular injury, where VWF...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Müller, Jochen P., Mielke, Salomé, Löf, Achim, Obser, Tobias, Beer, Christof, Bruetzel, Linda K., Pippig, Diana A., Vanderlinden, Willem, Lipfert, Jan, Schneppenheim, Reinhard, Benoit, Martin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2016
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747740/
https://ncbi.nlm.nih.gov/pubmed/26787887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516214113
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