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Force sensing by the vascular protein von Willebrand factor is tuned by a strong intermonomer interaction
The large plasma glycoprotein von Willebrand factor (VWF) senses hydrodynamic forces in the bloodstream and responds to elevated forces with abrupt elongation, thereby increasing its adhesiveness to platelets and collagen. Remarkably, forces on VWF are elevated at sites of vascular injury, where VWF...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4747740/ https://ncbi.nlm.nih.gov/pubmed/26787887 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516214113 |
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