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Multiplexed protein force spectroscopy reveals equilibrium protein folding dynamics and the low-force response of von Willebrand factor

Single-molecule force spectroscopy has provided unprecedented insights into protein folding, force regulation, and function. So far, the field has relied primarily on atomic force microscope and optical tweezers assays that, while powerful, are limited in force resolution, throughput, and require fe...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Löf, Achim, Walker, Philipp U., Sedlak, Steffen M., Gruber, Sophia, Obser, Tobias, Brehm, Maria A., Benoit, Martin, Lipfert, Jan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6754583/
https://ncbi.nlm.nih.gov/pubmed/31462494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1901794116
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