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Multiplexed protein force spectroscopy reveals equilibrium protein folding dynamics and the low-force response of von Willebrand factor

Single-molecule force spectroscopy has provided unprecedented insights into protein folding, force regulation, and function. So far, the field has relied primarily on atomic force microscope and optical tweezers assays that, while powerful, are limited in force resolution, throughput, and require fe...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Löf, Achim, Walker, Philipp U., Sedlak, Steffen M., Gruber, Sophia, Obser, Tobias, Brehm, Maria A., Benoit, Martin, Lipfert, Jan
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6754583/
https://ncbi.nlm.nih.gov/pubmed/31462494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1901794116
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