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Nicastrin functions to sterically hinder γ-secretase–substrate interactions driven by substrate transmembrane domain
γ-Secretase is an intramembrane-cleaving protease that processes many type-I integral membrane proteins within the lipid bilayer, an event preceded by shedding of most of the substrate’s ectodomain by α- or β-secretases. The mechanism by which γ-secretase selectively recognizes and recruits ectodoma...
Shranjeno v:
| izdano v: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4747693/ https://ncbi.nlm.nih.gov/pubmed/26699478 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512952113 |
| Oznake: |
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