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Nicastrin functions to sterically hinder γ-secretase–substrate interactions driven by substrate transmembrane domain

γ-Secretase is an intramembrane-cleaving protease that processes many type-I integral membrane proteins within the lipid bilayer, an event preceded by shedding of most of the substrate’s ectodomain by α- or β-secretases. The mechanism by which γ-secretase selectively recognizes and recruits ectodoma...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Bolduc, David M., Montagna, Daniel R., Gu, Yongli, Selkoe, Dennis J., Wolfe, Michael S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747693/
https://ncbi.nlm.nih.gov/pubmed/26699478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512952113
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