Caricamento...

Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1/FASN pathway in mice

Activation of the AKT/mTOR cascade and overexpression of c-Met have been implicated in the development of human hepatocellular carcinoma (HCC). To elucidate the functional crosstalk between the two pathways, we generated a model characterized by the combined expression of activated AKT and c-Met in...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Hu, Junjie, Che, Li, Li, Lei, Pilo, Maria G., Cigliano, Antonio, Ribback, Silvia, Li, Xiaolei, Latte, Gavinella, Mela, Marta, Evert, Matthias, Dombrowski, Frank, Zheng, Guohua, Chen, Xin, Calvisi, Diego F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746674/
https://ncbi.nlm.nih.gov/pubmed/26857837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20484
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !