Peripheral Adenosine A(3) Receptor Activation Causes Regulated Hypothermia in Mice That Is Dependent on Central Histamine H(1) Receptors

Adenosine can induce hypothermia, as previously demonstrated for adenosine A(1) receptor (A(1)AR) agonists. Here we use the potent, specific A(3)AR agonists MRS5698, MRS5841, and MRS5980 to show that adenosine also induces hypothermia via the A(3)AR. The hypothermic effect of A(3)AR agonists is inde...

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Vydáno v:J Pharmacol Exp Ther
Hlavní autoři: Carlin, Jesse Lea, Tosh, Dilip K., Xiao, Cuiying, Piñol, Ramón A., Chen, Zhoumou, Salvemini, Daniela, Gavrilova, Oksana, Jacobson, Kenneth A., Reitman, Marc L.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2016
Témata:
Endocrine and Diabetes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746492/
https://ncbi.nlm.nih.gov/pubmed/26606937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.229872
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