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Activation of neuronal adenosine A(1) receptors causes hypothermia through central and peripheral mechanisms

Extracellular adenosine, a danger signal, can cause hypothermia. We generated mice lacking neuronal adenosine A(1) receptors (A(1)AR, encoded by the Adora1 gene) to examine the contribution of these receptors to hypothermia. Intracerebroventricular injection of the selective A(1)AR agonist (Cl-ENBA,...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Province, Haley S., Xiao, Cuiying, Mogul, Allison S., Sahoo, Ankita, Jacobson, Kenneth A., Piñol, Ramón A., Gavrilova, Oksana, Reitman, Marc L.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7743955/
https://ncbi.nlm.nih.gov/pubmed/33326493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0243986
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