Activation of neuronal adenosine A(1) receptors causes hypothermia through central and peripheral mechanisms

Extracellular adenosine, a danger signal, can cause hypothermia. We generated mice lacking neuronal adenosine A(1) receptors (A(1)AR, encoded by the Adora1 gene) to examine the contribution of these receptors to hypothermia. Intracerebroventricular injection of the selective A(1)AR agonist (Cl-ENBA,...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Province, Haley S., Xiao, Cuiying, Mogul, Allison S., Sahoo, Ankita, Jacobson, Kenneth A., Piñol, Ramón A., Gavrilova, Oksana, Reitman, Marc L.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2020
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7743955/
https://ncbi.nlm.nih.gov/pubmed/33326493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0243986
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