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Peripheral Adenosine A(3) Receptor Activation Causes Regulated Hypothermia in Mice That Is Dependent on Central Histamine H(1) Receptors

Adenosine can induce hypothermia, as previously demonstrated for adenosine A(1) receptor (A(1)AR) agonists. Here we use the potent, specific A(3)AR agonists MRS5698, MRS5841, and MRS5980 to show that adenosine also induces hypothermia via the A(3)AR. The hypothermic effect of A(3)AR agonists is inde...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Pharmacol Exp Ther
Main Authors: Carlin, Jesse Lea, Tosh, Dilip K., Xiao, Cuiying, Piñol, Ramón A., Chen, Zhoumou, Salvemini, Daniela, Gavrilova, Oksana, Jacobson, Kenneth A., Reitman, Marc L.
פורמט: Artigo
שפה:Inglês
יצא לאור: The American Society for Pharmacology and Experimental Therapeutics 2016
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746492/
https://ncbi.nlm.nih.gov/pubmed/26606937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.229872
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