Peripheral Adenosine A(3) Receptor Activation Causes Regulated Hypothermia in Mice That Is Dependent on Central Histamine H(1) Receptors

Adenosine can induce hypothermia, as previously demonstrated for adenosine A(1) receptor (A(1)AR) agonists. Here we use the potent, specific A(3)AR agonists MRS5698, MRS5841, and MRS5980 to show that adenosine also induces hypothermia via the A(3)AR. The hypothermic effect of A(3)AR agonists is inde...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Carlin, Jesse Lea, Tosh, Dilip K., Xiao, Cuiying, Piñol, Ramón A., Chen, Zhoumou, Salvemini, Daniela, Gavrilova, Oksana, Jacobson, Kenneth A., Reitman, Marc L.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2016
Assuntos:
Endocrine and Diabetes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746492/
https://ncbi.nlm.nih.gov/pubmed/26606937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.229872
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