Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors

Intraperitoneal administration of the melanocortin agonist melanotan II (MTII) to mice causes a profound, transient hypometabolism/hypothermia. It is preserved in mice lacking any one of melanocortin receptors 1, 3, 4, or 5, suggesting a mechanism independent of the canonical melanocortin receptors....

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Publicado en:Am J Physiol Endocrinol Metab
Autores principales: Jain, Shalini, Panyutin, Anna, Liu, Naili, Xiao, Cuiying, Piñol, Ramón A., Pundir, Priyanka, Girardet, Clémence, Butler, Andrew A., Dong, Xinzhong, Gavrilova, Oksana, Reitman, Marc L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2018
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6171009/
https://ncbi.nlm.nih.gov/pubmed/29812984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00024.2018
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