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Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors
Intraperitoneal administration of the melanocortin agonist melanotan II (MTII) to mice causes a profound, transient hypometabolism/hypothermia. It is preserved in mice lacking any one of melanocortin receptors 1, 3, 4, or 5, suggesting a mechanism independent of the canonical melanocortin receptors....
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| Publicado en: | Am J Physiol Endocrinol Metab |
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| Autores principales: | , , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Physiological Society
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6171009/ https://ncbi.nlm.nih.gov/pubmed/29812984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00024.2018 |
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