PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness

Cancer stem cells (CSCs) contribute to tumour heterogeneity, therapy resistance and metastasis. However, the regulatory mechanisms of cancer cell stemness remain elusive. Here we identify PCNA-associated factor (PAF) as a key molecule that controls cancer cell stemness. PAF is highly expressed in br...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Wang, Xin, Jung, Youn-Sang, Jun, Sohee, Lee, Sunhye, Wang, Wenqi, Schneider, Andrea, Sun Oh, Young, Lin, Steven H., Park, Bum-Joon, Chen, Junjie, Keyomarsi, Khandan, Park, Jae-Il
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743006/
https://ncbi.nlm.nih.gov/pubmed/26843124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10633
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