PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness

Cancer stem cells (CSCs) contribute to tumour heterogeneity, therapy resistance and metastasis. However, the regulatory mechanisms of cancer cell stemness remain elusive. Here we identify PCNA-associated factor (PAF) as a key molecule that controls cancer cell stemness. PAF is highly expressed in br...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Wang, Xin, Jung, Youn-Sang, Jun, Sohee, Lee, Sunhye, Wang, Wenqi, Schneider, Andrea, Sun Oh, Young, Lin, Steven H., Park, Bum-Joon, Chen, Junjie, Keyomarsi, Khandan, Park, Jae-Il
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743006/
https://ncbi.nlm.nih.gov/pubmed/26843124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10633
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