Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth

In soft tissue sarcomas (STS), low intratumoural O(2) (hypoxia) is a poor prognostic indicator. HIF-1α mediates key transcriptional responses to hypoxia, and promotes STS metastasis; however, the role of the related HIF-2α protein is unknown. Surprisingly, here we show that HIF-2α inhibits high-grad...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Nakazawa, Michael S., Eisinger-Mathason, T. S. Karin, Sadri, Navid, Ochocki, Joshua D., Gade, Terence P. F., Amin, Ruchi K., Simon, M. Celeste
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742834/
https://ncbi.nlm.nih.gov/pubmed/26837714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10539
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