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Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth
In soft tissue sarcomas (STS), low intratumoural O(2) (hypoxia) is a poor prognostic indicator. HIF-1α mediates key transcriptional responses to hypoxia, and promotes STS metastasis; however, the role of the related HIF-2α protein is unknown. Surprisingly, here we show that HIF-2α inhibits high-grad...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4742834/ https://ncbi.nlm.nih.gov/pubmed/26837714 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10539 |
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