Design and Optimization of Anti-amyloid Domain Antibodies Specific for β-Amyloid and Islet Amyloid Polypeptide

Antibodies with conformational specificity are important for detecting and interfering with polypeptide aggregation linked to several human disorders. We are developing a motif-grafting approach for designing lead antibody candidates specific for amyloid-forming polypeptides such as the Alzheimer pe...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Lee, Christine C., Julian, Mark C., Tiller, Kathryn E., Meng, Fanling, DuConge, Sarah E., Akter, Rehana, Raleigh, Daniel P., Tessier, Peter M.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2016
Sujets:
Protein Structure and Folding
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742750/
https://ncbi.nlm.nih.gov/pubmed/26601942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.682336
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