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Differential effects of serine side chain interactions in amyloid formation by islet amyloid polypeptide
Islet amyloid polypeptide (IAPP), a 37 residue polypeptide, is the main protein component of islet amyloid deposits produced in the pancreas in Type 2 diabetes. Human IAPP contains five serine residues at positions 19, 20, 28, 29, and 34. Models of the IAPP amyloid fibril indicate a structure compos...
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| Publicado no: | Protein Sci |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley & Sons, Inc.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6954694/ https://ncbi.nlm.nih.gov/pubmed/31705766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3782 |
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