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Morin hydrate inhibits amyloid formation by islet amyloid polypeptide and disaggregates amyloid fibers

The polypeptide hormone Islet Amyloid Polypeptide (IAPP, amylin) is responsible for islet amyloid formation in type-2 diabetes and in islet cell transplants, where it may contribute to graft failure. Human IAPP is extremely amyloidogenic and fewer inhibitors of IAPP amyloid formation have been repor...

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Autors principals: Noor, Harris, Cao, Ping, Raleigh, Daniel P
Format: Artigo
Idioma:Inglês
Publicat: Wiley Subscription Services, Inc., A Wiley Company 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375438/
https://ncbi.nlm.nih.gov/pubmed/22238175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2023
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