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Morin hydrate inhibits amyloid formation by islet amyloid polypeptide and disaggregates amyloid fibers
The polypeptide hormone Islet Amyloid Polypeptide (IAPP, amylin) is responsible for islet amyloid formation in type-2 diabetes and in islet cell transplants, where it may contribute to graft failure. Human IAPP is extremely amyloidogenic and fewer inhibitors of IAPP amyloid formation have been repor...
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Main Authors: | , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Wiley Subscription Services, Inc., A Wiley Company
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3375438/ https://ncbi.nlm.nih.gov/pubmed/22238175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2023 |
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