Targeting mitochondrial RNA polymerase in acute myeloid leukemia

Acute myeloid leukemia (AML) cells have high oxidative phosphorylation and mitochondrial mass and low respiratory chain spare reserve capacity. We reasoned that targeting the mitochondrial RNA polymerase (POLRMT), which indirectly controls oxidative phosphorylation, represents a therapeutic strategy...

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Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Bralha, Fernando N., Liyanage, Sanduni U., Hurren, Rose, Wang, Xiaoming, Son, Meong Hi, Fung, Thomas A., Chingcuanco, Francine B., Tung, Aveline Y. W., Andreazza, Ana C., Psarianos, Pamela, Schimmer, Aaron D., Salmena, Leonardo, Laposa, Rebecca R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2015
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741925/
https://ncbi.nlm.nih.gov/pubmed/26484416
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