Targeting mitochondrial RNA polymerase in acute myeloid leukemia

Acute myeloid leukemia (AML) cells have high oxidative phosphorylation and mitochondrial mass and low respiratory chain spare reserve capacity. We reasoned that targeting the mitochondrial RNA polymerase (POLRMT), which indirectly controls oxidative phosphorylation, represents a therapeutic strategy...

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Vydáno v:Oncotarget
Hlavní autoři: Bralha, Fernando N., Liyanage, Sanduni U., Hurren, Rose, Wang, Xiaoming, Son, Meong Hi, Fung, Thomas A., Chingcuanco, Francine B., Tung, Aveline Y. W., Andreazza, Ana C., Psarianos, Pamela, Schimmer, Aaron D., Salmena, Leonardo, Laposa, Rebecca R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741925/
https://ncbi.nlm.nih.gov/pubmed/26484416
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