Leveraging increased cytoplasmic nucleoside kinase activity to target mtDNA and oxidative phosphorylation in AML

Mitochondrial DNA (mtDNA) biosynthesis requires replication factors and adequate nucleotide pools from the mitochondria and cytoplasm. We performed gene expression profiling analysis of 542 human acute myeloid leukemia (AML) samples and identified 55% with upregulated mtDNA biosynthesis pathway expr...

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書誌詳細
出版年:Blood
主要な著者: Liyanage, Sanduni U., Hurren, Rose, Voisin, Veronique, Bridon, Gaëlle, Wang, Xiaoming, Xu, ChangJiang, MacLean, Neil, Siriwardena, Thirushi P., Gronda, Marcela, Yehudai, Dana, Sriskanthadevan, Shrivani, Avizonis, Daina, Shamas-Din, Aisha, Minden, Mark D., Bader, Gary D., Laposa, Rebecca, Schimmer, Aaron D.
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Hematology 2017
主題:
Myeloid Neoplasia
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766841/
https://ncbi.nlm.nih.gov/pubmed/28283480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-10-741207
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