Leveraging increased cytoplasmic nucleoside kinase activity to target mtDNA and oxidative phosphorylation in AML

Mitochondrial DNA (mtDNA) biosynthesis requires replication factors and adequate nucleotide pools from the mitochondria and cytoplasm. We performed gene expression profiling analysis of 542 human acute myeloid leukemia (AML) samples and identified 55% with upregulated mtDNA biosynthesis pathway expr...

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Publicado en:Blood
Autores principales: Liyanage, Sanduni U., Hurren, Rose, Voisin, Veronique, Bridon, Gaëlle, Wang, Xiaoming, Xu, ChangJiang, MacLean, Neil, Siriwardena, Thirushi P., Gronda, Marcela, Yehudai, Dana, Sriskanthadevan, Shrivani, Avizonis, Daina, Shamas-Din, Aisha, Minden, Mark D., Bader, Gary D., Laposa, Rebecca, Schimmer, Aaron D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2017
Materias:
Myeloid Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766841/
https://ncbi.nlm.nih.gov/pubmed/28283480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-10-741207
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