Leveraging increased cytoplasmic nucleoside kinase activity to target mtDNA and oxidative phosphorylation in AML

Mitochondrial DNA (mtDNA) biosynthesis requires replication factors and adequate nucleotide pools from the mitochondria and cytoplasm. We performed gene expression profiling analysis of 542 human acute myeloid leukemia (AML) samples and identified 55% with upregulated mtDNA biosynthesis pathway expr...

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Dades bibliogràfiques
Publicat a:Blood
Autors principals: Liyanage, Sanduni U., Hurren, Rose, Voisin, Veronique, Bridon, Gaëlle, Wang, Xiaoming, Xu, ChangJiang, MacLean, Neil, Siriwardena, Thirushi P., Gronda, Marcela, Yehudai, Dana, Sriskanthadevan, Shrivani, Avizonis, Daina, Shamas-Din, Aisha, Minden, Mark D., Bader, Gary D., Laposa, Rebecca, Schimmer, Aaron D.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2017
Matèries:
Myeloid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766841/
https://ncbi.nlm.nih.gov/pubmed/28283480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-10-741207
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