Metabolic Adaptation to Chronic Inhibition of Mitochondrial Protein Synthesis in Acute Myeloid Leukemia Cells

Recently, we demonstrated that the anti-bacterial agent tigecycline preferentially induces death in leukemia cells through the inhibition of mitochondrial protein synthesis. Here, we sought to understand mechanisms of resistance to tigecycline by establishing a leukemia cell line resistant to the dr...

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Detalhes bibliográficos
Main Authors: Jhas, Bozhena, Sriskanthadevan, Shrivani, Skrtic, Marko, Sukhai, Mahadeo A., Voisin, Veronique, Jitkova, Yulia, Gronda, Marcela, Hurren, Rose, Laister, Rob C., Bader, Gary D., Minden, Mark D., Schimmer, Aaron D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592803/
https://ncbi.nlm.nih.gov/pubmed/23520503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058367
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