A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia

Acute myeloid leukemia (AML) cells meet the higher energy, metabolic, and signaling demands of the cell by increasing mitochondrial biogenesis and mitochondrial protein translation. Blocking mitochondrial protein synthesis through genetic and chemical approaches kills human AML cells at all stages o...

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Detalles Bibliográficos
Publicado en:Cancer Med
Main Authors: Reed, Gregory A., Schiller, Gary J., Kambhampati, Suman, Tallman, Martin S., Douer, Dan, Minden, Mark D., Yee, Karen W., Gupta, Vikas, Brandwein, Joseph, Jitkova, Yulia, Gronda, Marcela, Hurren, Rose, Shamas‐Din, Aisha, Schuh, Andre C., Schimmer, Aaron D.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2016
Assuntos:
Clinical Cancer Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5119957/
https://ncbi.nlm.nih.gov/pubmed/27734609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.845
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