A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia

Acute myeloid leukemia (AML) cells meet the higher energy, metabolic, and signaling demands of the cell by increasing mitochondrial biogenesis and mitochondrial protein translation. Blocking mitochondrial protein synthesis through genetic and chemical approaches kills human AML cells at all stages o...

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Publicat a:Cancer Med
Autors principals: Reed, Gregory A., Schiller, Gary J., Kambhampati, Suman, Tallman, Martin S., Douer, Dan, Minden, Mark D., Yee, Karen W., Gupta, Vikas, Brandwein, Joseph, Jitkova, Yulia, Gronda, Marcela, Hurren, Rose, Shamas‐Din, Aisha, Schuh, Andre C., Schimmer, Aaron D.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
Matèries:
Clinical Cancer Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5119957/
https://ncbi.nlm.nih.gov/pubmed/27734609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.845
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