The thymidine dideoxynucleoside analog, alovudine, inhibits the mitochondrial DNA polymerase γ, impairs oxidative phosphorylation and promotes monocytic differentiation in acute myeloid leukemia

Mitochondrial DNA encodes 13 proteins that comprise components of the respiratory chain that maintain oxidative phosphorylation. The replication of mitochondrial DNA is performed by the sole mitochondrial DNA polymerase γ. As acute myeloid leukemia (AML) cells and stem cells have an increased relian...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Haematologica
मुख्य लेखकों: Yehudai, Dana, Liyanage, Sanduni U., Hurren, Rose, Rizoska, Biljana, Albertella, Mark, Gronda, Marcela, Jeyaraju, Danny V, Wang, Xiaoming, Barghout, Samir H., MacLean, Neil, Siriwardena, Thirushi P., Jitkova, Yulia, Targett-Adams, Paul, Schimmer, Aaron D.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Ferrata Storti Foundation 2019
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6518883/
https://ncbi.nlm.nih.gov/pubmed/30573504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.195172
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