The thymidine dideoxynucleoside analog, alovudine, inhibits the mitochondrial DNA polymerase γ, impairs oxidative phosphorylation and promotes monocytic differentiation in acute myeloid leukemia

Mitochondrial DNA encodes 13 proteins that comprise components of the respiratory chain that maintain oxidative phosphorylation. The replication of mitochondrial DNA is performed by the sole mitochondrial DNA polymerase γ. As acute myeloid leukemia (AML) cells and stem cells have an increased relian...

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Publicado no:Haematologica
Main Authors: Yehudai, Dana, Liyanage, Sanduni U., Hurren, Rose, Rizoska, Biljana, Albertella, Mark, Gronda, Marcela, Jeyaraju, Danny V, Wang, Xiaoming, Barghout, Samir H., MacLean, Neil, Siriwardena, Thirushi P., Jitkova, Yulia, Targett-Adams, Paul, Schimmer, Aaron D.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6518883/
https://ncbi.nlm.nih.gov/pubmed/30573504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.195172
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