The thymidine dideoxynucleoside analog, alovudine, inhibits the mitochondrial DNA polymerase γ, impairs oxidative phosphorylation and promotes monocytic differentiation in acute myeloid leukemia

Mitochondrial DNA encodes 13 proteins that comprise components of the respiratory chain that maintain oxidative phosphorylation. The replication of mitochondrial DNA is performed by the sole mitochondrial DNA polymerase γ. As acute myeloid leukemia (AML) cells and stem cells have an increased relian...

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Pubblicato in:Haematologica
Autori principali: Yehudai, Dana, Liyanage, Sanduni U., Hurren, Rose, Rizoska, Biljana, Albertella, Mark, Gronda, Marcela, Jeyaraju, Danny V, Wang, Xiaoming, Barghout, Samir H., MacLean, Neil, Siriwardena, Thirushi P., Jitkova, Yulia, Targett-Adams, Paul, Schimmer, Aaron D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ferrata Storti Foundation 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6518883/
https://ncbi.nlm.nih.gov/pubmed/30573504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.195172
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